Dr Theophile Bigirumurame

Research Fellow Statistician

Theophile Bigirumurame is a Research Fellow statistician (50% FTE) in the Enabling Methodologies theme of the NIHR Applied Research Collaboration (ARC) North East and North Cumbria (NENC).

He is also a statistician (50% FTE) in the Biostatistics Research Group within the Newcastle University Population Health Sciences Institute.


Theophile has several years of research experience as a statistician. He provides statistical support in the analysis of clinical trials and other evaluation studies.

Theophile contributes to the statistical design and analysis planning at the funding application stages of new projects, ensuring that any aspects of the study concerning the data quality and data credibility which may affect the analysis are considered, discussed and the key decisions documented appropriately. He also conducts methodological research focusing on the design and development of quantitative methods in the context of the implementation of complex interventions, in public health and social care.

Areas of interest

Theophile is interested in, and can help you with:

  • The integration of multi-source data in the statistical analyses
  • Multilevel modelling (clustered or longitudinal)
  • The use of machine learning
  • Better use of data from routinely collected data, registries data


  • Bigirumurame Theophile, Germaine Uwimpuhwe, and James Wason. “Sequential multiple assignment randomized trial studies should report all key components: a systematic review.” Journal of Clinical Epidemiology (2021).
  • Grayling MJ, Bigirumurame T, Cherlin S, Ouma L, Zheng H, Wason J (2021). Innovative trial approaches in immune-mediated inflammatory diseases: Current use and future potential. BMC Rheumatol 2021; 5:21.
  • Slight SP, Tolley CL, Bates DW, Fraser R, Bigirumurame T, Kasim A, Balaskonis K, Narrie S, Heed A, Orav EJ, Watson NW, 2019. Medication errors and adverse drug events in a UK hospital during the optimisation of electronic prescriptions: a prospective observational study. The Lancet Digital Health, 1(8), e403-e412
  • Jameson SS, Asaad A, Diament M, Kasim A, Bigirumurame T, Baker P, Mason J, Partington P, Reed M., 2019. Antibiotic-loaded bone cement is associated with a lower risk of revision following primary cemented total knee arthroplasty: an analysis of 731,214 cases using National Joint Registry data. The Bone & Joint Journal, 101-B(11), p.1331-1347.
  • Bigirumurame T; Kasim, Adetayo (2017) Can testing clinical significance reduce false positive rates in clinical trials? A snap review, BMJ research Notes 10: 77

Get in touch

Email: theophile.bigirumurame@newcastle.ac.uk

Follow this link to view Theophile’s profile at Newcastle University